ORİJİNAL ARAŞTIRMALAR
Polikistik Ovary Sendromlu Ergen ve Yetişkin Hastalar Arasındaki Klinik, Endokrinolojik ve Biyokimyasal Farkların Değerlendirilmesi
Evaluation of the Clinical, Endocrinological, and Biochemical Differences Between Adolescent and Adult Patients with Polycystic Ovary Syndrome
Received Date : 15 Dec 2020
Accepted Date : 23 Jan 2021
Available Online : 03 Feb 2021
Ebru YÜCEa, Recai PABUCCUb, Müge KESKİNb, Tufan ARSLANCAb, Emre Göksan PABUÇCUb
aYüksek İhtisas Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum ABD, Ankara, TÜRKİYE
bUfuk Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum ABD, Ankara, TÜRKİYE
Doi: 10.24074/tjrms.2020-80616 - Makale Dili: TR
TJRMS. 2020;4(1):15-23
ÖZET
Amaç: Polikistik Over Sendromu (PKOS) erken başlangıçlı ve kronik seyreden bir hastalıktır ve etiyopatogenezi tam olarak açıklanamamaktadır.
Bu durum teşhis karmaşıklığına neden olur. Bu çalışmanın amacı, erken yaşta doğru PKOS tanısı elde etmek için PKOS'lu adolesan ve erişkin
hastaların klinik, biyokimyasal ve endokrinolojik parametrelerini karşılaştırmaktır. Gereç ve Yöntemler: Bu çalışmaya 2003 Rotterdam
ASRM / ESHRE kriterlerine göre PKOS tanısı almış 218 hasta dahil edildi. Hastalar 18 yaşından küçük veya 18 yaşından büyük olmalarına göre
ergen ve yetişkin olarak iki gruba ayrıldı. Bu çalışma, gözlemsel bir çalışma olarak tasarlanmıştır. Bulgular: 112 ergen ve 106 yetişkinin analizlerinde
sadece yaş (p <0.001), jinekolojik yaş (p <0.001) ve hirsutizm varlığı (p = 0.01) istatistiksel olarak anlamlı farklılık gösterdi. Biyokimyasal
ve klinik hiperandrojenizm oranları ergenlerde anlamlı olarak daha yüksek bulundu. Analizler, ergenlerde serbest testosteron düzeylerinin
anlamlı olarak yüksek (p <0.001) ve toplam kolesterol (p <0.001), LDL (p <0.001) ve HDL düzeylerinin (p = 0.03) anlamlı olarak düşük olduğunu
ortaya koydu. Sonuçlar: Bu çalışma PKOS'lu ergen ve yetişkin hastalar arasında bazı farklılıklar olduğunu göstermiştir. Ergen PKOS tanısı
ile ilgili devam eden tartışmaları netleştirmek için daha fazla randomize kontrollü çalışmalara ihtiyaç vardır.
Anahtar Kelimeler: Adölesan, polikistik over sendromu, erişkin
ABSTRACT
Objective: Polycystic Ovary Syndrome (PCOS) is a disease with early onset and chronic course, and its etiopathogenesis cannot be exactly clarified.
This situation causes a diagnostic complexity. The objective of this study is comparing the clinical, biochemical, and endocrinologic parameters
of adolescent and adult patients with PCOS for achieving an accurate diagnosis of PCOS at early ages. Material and Methods: This
study included 218 patients that diagnosed as PCOS according to criteria of 2003 Rotterdam ASRM/ESHRE. Patients were separated into two
groups as adolescents and adults according to whether they are younger or older than 18 years of age. This study is designed as an observational
study. Results: In the analyses of 112 adolescents and 106 adults, only age (p<0.001), gynecological age (p<0.001) and presence of hirsutism
(p=0.01) showed statistically significant differences. Biochemical and clinical hyperandrogenism rates were found to be significantly higher in
adolescents. Analyses revealed that free testosterone levels were significantly high (p<0.001), and total cholesterol (p<0.001), LDL (p<0.001) and
HDL levels (p=0.03) were significantly low in adolescents. Conclusions: This study demonstrated some differences between adolescent and
adult patients with PCOS. Further randomized controlled trials are needed to clarify the ongoing discussions about the diagnosis of adolescent
PCOS.
Keywords: Polycystic ovary syndrome, adolescents, adults, difference
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