ISSN: 2148-8274 / E-ISSN: 2587-0084
, Türk Üreme Tıbbı ve Cerrahisi
Dergisi

Turkish Journal of Reproductive Medicine and Surgery

Dernek Sitesi
Kayıtlı İndexler
DERLEMELER
Kemoterapinin Uterusa Toksik Etkileri ve Korunma Yöntemleri
Uterine effects of Chemotherapy and Preventive Methods
Received Date : 28 Mar 2023
Accepted Date : 03 Apr 2023
Available Online : 06 Apr 2023
Özet PDF Benzer Makaleler
Mehmet Zeki TANERa, Gülnur TAKE KAPLANOĞLUb
aGazi Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum ABD, Ankara, Türkiye bGazi Üniversitesi Tıp Fakültesi, Histoloji ve Embriyoloji ABD, Ankara, Türkiye
Doi: 10.24074/tjrms.2023-97020 - Makale Dili: TR
TJRMS. 2023;7(1):21-34
ÖZET
Kanser tedavisinde kullanılan tıbbi ve cerrahi yöntemlerin üreme organlarına zararlı etkileri vardır. Bu etkilere bağlı; infertilite, fertilitede azalma, abortus, erken doğum eylemi ve erken doğum, düşük doğum ağırlığı, gebelik komplikasyonlarında artış izlenmektedir. Bu konuda üzerinde en çok durulan ve incelenen gonadal toksisitedir. Buna yönelik uyulması gereken kurallar ve hasta danışmanlığı bilgileri rehberler halinde yayınlanmaktadır. Uterus üzerine olan etkilerden radyoterapi ayrıntılı olarak incelenmiştir. Ancak kemoterapötik ajanların etkileri , önleme yöntemleri üzerinde durulmamıştır. Bu derleme makelede, antrasiklin grubu kemoterapötik Doxorubisinin ; bir çok organ ve dokuya özellikle iskelet, üriner, mide barsak, damar düz kasları düz kaslar ve özellikle kalp kasına olan toksik etkileri, etki mekanizmaları, toksik etki mekanizmaları ve önleme yöntemleri incelenecektir. Uterin toksisite ayrıntılı incelenecek ve önleme önerileri gözden geçirilecektir.
Anahtar Kelimeler: Antineoplastik birleşik kemoterapi protokolleri; doxorubisin; toksisite; uterus; infertilite; gebelik; gebelik komplikasyonları; önleme ve kontrol; antioksidanlar; egzersiz
ABSTRACT
The treatment modalities of cancer have detrimental effects on reproductive organs and function. The clinical Picture of these effects are; decreased fertility rate, infertility, abortion, preterm labor and delivery, low birth weight and increased preganancy complications. Gonadal toxicities are the most investigated and ,regulation and counseiling rules has been settled. There are societies guidelines for prevention and management of this complications. The effects of radiotherapy on uterus are extensively studied. But, research on effects, prevention and treatment of chemotherapeutics are scanty. In this review; we aim to evaluate the effects of antacyclins chemothepeuticss, mainly doxorubicin, effects on uterus, which is higly toxic on several organs, skletal muscle and urinary system, gastrointestinal system, vascular smooth muscles, and especially on cardiac tissue. The therapeutic and toxic mechanims, and clinical results of their effects on uterus, will be reviewed. Uterin toxicity, preventive intervention and treatment will be evaluated in detail.
Keywords: Antineoplastic combined chemotherapy protocol; doxorubicin; toxicity; uterus; infertility; pregnancy; pregnancy complications; prevention and control; antioxidants; exercises
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