DERLEMELER
Gebelikte COVID-19 Enfeksiyonunda Enflamatuvar Yanıt ve Obstetrik Komplikasyonlar
Inflammatory Response to COVID-19 Infection During Pregnancy and Obstetrical Complications
Received Date : 03 May 2021
Accepted Date : 09 Jul 2021
Available Online : 16 Aug 2021
Hikmet Tunç TİMURa, Emre BAYRAMb, Mehmet Eyüphan ÖZGÖZENb, Erkan ÇAĞLIYANb
aNiğde Çiftlik Devlet Hastanesi, Niğde, TÜRKİYE
bDokuz Eylül Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum ABD, İzmir, TÜRKİYE
Doi: 10.24074/tjrms.2021-84258 - Makale Dili: TR
TJRMS. 2021;5(2):55-61
ÖZET
2019 yılının sonlarında tespit edilen COVID-19 (SARS-CoV-2 virüsü), 2020 yılının başında pandemi özelliği kazandı ve tüm dünyada milyonlarca
kişinin enfekte olmasına sebep oldu. Hafif semptomlardan ölümcül çoklu organ yetmezliğine kadar geniş bir yelpazede etki gösterebilen
bu hastalık maalesef birçok gebe kadında da izlendi. Gebeliğin COVID-19 kliniğini nasıl etkilediğine dair ortak bir görüş henüz oluşmadı. Erken
dönem verileri, enfekte kadınlarda preterm doğum, intrauterin büyüme geriliği, düşük doğum ağırlığı gibi komplikasyonların daha sık görüldüğünü
işaret ediyor. Hastalık hakkında daha çok bilgi birikimi oluştuğunda, tedavi seçeneklerinin de artmasıyla birlikte ileride olası komplikasyonların
ve bunlara sebep olan ilişkilerin daha çok aydınlatılabileceği beklenmektedir.
Anahtar Kelimeler: COVID-19, SARS-CoV-2, gebelik sonucu, gebelik komplikasyonları
ABSTRACT
COVID-19 (SARS-CoV-2 Virus) was detected at the end of year 2019 and became a pandemic in early 2020. Millions of people were infected
in the entire world. The clinical presentation varied from mild symptoms to multi organ failure and eventually death. The disease was unfortunately
seen among many pregnant women. Pregnancy may be a risk factor for poor prognosis. Early data suggests that COVID-19 is associated
with preterm birth, low birth weight and intrauterine growth restriction. Possible complications and associations that contribute to these complications
are expected to be enlightened in the future as more studies will provide more information about the disease and make more treatment
options available.
Keywords: COVID-19, SARS-CoV-2, pregnancy outcome, pregnancy complications
REFERANSLAR
- Gorbalenya AE, Baker SC, Baric RS, de Groot RJ, Drosten C, Gulyaeva AA, et al. The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol. 2020;5(4):536-44. [Crossref]
- Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395(10224):565-74. [Crossref]
- Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-33. [Crossref]
- Perlman S. Another Decade, Another Coronavirus. N Engl J Med. 2020;382(8):760-2. [Crossref]
- Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. J Virol. 2020;94(7):1-9. [Crossref]
- Wu Y-C, Chen C-S, Chan Y-J. The outbreak of COVID-19. J Chinese Med Assoc. 2020; 83(3): 217-20. [Crossref]
- Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W, et al. viruses Virology, Epidemiology, Pathogenesis, and Control of COVID-19.
- Meyerowitz EA, Richterman A, Gandhi RT, Sax PE. Transmission of SARS-CoV-2: A Review of Viral, Host, and Environmental Factors. Ann Intern Med. 2020 Sep 17. [Crossref]
- Klompas M, Baker MA, Rhee C. Airborne Transmission of SARS-CoV-2: Theoretical Considerations and Available Evidence. Vol. 324, JAMA - Journal of the American Medical Association. American Medical Association; 2020.p. 441-2. [Crossref]
- Wang W, Xu Y, Gao R, Lu R, Han K, Wu G, et al. Detection of SARS-CoV-2 in Different Types of Clinical Specimens. Vol. 323, JAMA - Journal of the American Medical Association. American Medical Association; 2020. p. 1843-4. [Crossref]
- Hegewald MJ, Crapo RO. Respiratory Physiology in Pregnancy. Clin Chest Med. 2011; 32(1):1-13. [Crossref]
- Narang K, Enninga EAL, Gunaratne MDSK, Ibirogba ER, Trad ATA, Elrefaei A, et al. SARS-CoV-2 Infection and COVID-19 During Pregnancy: A Multidisciplinary Review. Vol. 95, Mayo Clinic Proceedings. Elsevier Ltd; 2020. p.1750-65. [Crossref]
- Gao YJ, Ye L, Zhang JS, Yin YX, Liu M, Yu HB, et al. Clinical features and outcomes of pregnant women with COVID-19: A systematic review and meta-analysis. BMC Infect Dis. 2020;20(1):564. [Crossref]
- Wu D, Fang D, Wang R, Deng D, Liao S. Management of Pregnancy during the COVID‐19 Pandemic. Glob Challenges. 2021;5(2): 20000 52. [Crossref]
- Eguchi S, Kawai T, Scalia R, Rizzo V. Understanding Angiotensin II type 1 receptor signaling in vascular pathophysiology. Hypertension. 2018;71(5):804-10. [Crossref]
- Jing Y, Li R-Q, Hao-Ran W, Hao-Ran C, Ya-Bin L, Yang G, et al. Potential influence of COVID-19/ACE2 on the female reproductive system.
- McElvaney OJ, McEvoy NL, McElvaney OF, Carroll TP, Murphy MP, Dunlea DM, et al. Characterization of the inflammatory response to severe COVID-19 Illness. Am J Respir Crit Care Med. 2020;202(6):812-21. [Crossref]
- Phoswa WN, Khaliq OP. Is pregnancy a risk factor of COVID-19? Eur J Obstet Gynecol Reprod Biol. 2020;252:605-9. [Crossref]
- Breslin N, Baptiste C, Miller R, Fuchs K, Goffman D, Gyamfi-Bannerman C, et al. Coronavirus disease 2019 in pregnancy: early lessons. Am J Obstet Gynecol MFM. 2020; 2(2):100111. [Crossref]
- Khalil A, Kalafat E, Benlioglu C, O'brien P, Morris E, Draycott T, et al. SARS-CoV-2 infection in pregnancy: A systematic review and meta-analysis of clinical features and pregnancy outcomes. EClinical Medicine. 2020;25: 100446. [Crossref]
- Kayem G, Lecarpentier E, Deruelle P, Bretelle F, Azria E, Blanc J, et al. A snapshot of the Covid-19 pandemic among pregnant women in France. J Gynecol Obstet Hum Reprod. 2020;49(7):101826. [Crossref]
- Knight M, Bunch K, Vousden N, Morris E, Simpson N, Gale C, et al. Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: National population based cohort study. BMJ. 2020;369. 2107. doi: 10.1136/bmj. m2 107. [Crossref]
- Takemoto MLS, Menezes M de O, Andreucci CB, Nakamura‐Pereira M, Amorim MMR, Katz L, et al. The tragedy of COVID‐19 in Brazil: 124 maternal deaths and counting. Int J Gynecol Obstet. 2020;151(1):154-6. [Crossref]
- Algarroba GN, Rekawek P, Vahanian SA, Khullar P, Palaia T, Peltier MR, et al. Visualization of severe acute respiratory syndrome coronavirus 2 invading the human placenta using electron microscopy. Am J Obstet Gynecol. 2020;223(2):275-8. [Crossref]
- Mulvey JJ, Magro CM, Ma LX, Nuovo GJ, Baergen RN. Analysis of complement deposition and viral RNA in placentas of COVID-19 patients. 2020;46:151530. [Crossref]
- Zhang P, Heyman T, Greechan M, Dygulska B, Al Sayyed F, Narula P, et al. Maternal, neonatal and placental characteristics of SARS-CoV-2 positive mothers. 2021:1-9. [Crossref]
- Wong YP, Khong TY, Tan GC. The Effects of COVID-19 on Placenta and Pregnancy: What do we know so far? Diagnostics. 2021;11(1): 94. [Crossref]
- Salem D, Katranji F, Bakdash T. COVID-19 infection in pregnant women: Review of maternal and fetal outcomes. Int J Gynecol Obstet. 2020;(December 2020):291-8. [Crossref]
- Pique-Regi R, Romero R, Tarca AL, Luca F, Xu Y, Alazizi A, et al. Does the human placenta express the canonical cell entry mediators for sars-cov-2? Elife. 2020;9:1-15. [Crossref]
- Penfield CA, Brubaker SG, Limaye MA, Lighter J, Ratner AJ, Thomas KM, et al. Detection of severe acute respiratory syndrome coronavirus 2 in placental and fetal membrane samples. Am J Obstet Gynecol MFM. 2020; 2(3):100133. [Crossref]
- Yang Z, Liu Y. Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review. 2020. [Crossref]
- Vivanti AJ, Vauloup-Fellous C, Prevot S, Zupan V, Suffee C, Do Cao J, et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020;11(1):1-7. [Crossref]
- Wastnedge EAN, Reynolds RM, van Boeckel SR, Stock SJ, Denison FC, Maybin JA, et al. Pregnancy and COVID-19. Physiol Rev. 2021;101(1):303-18. [Crossref]
- Dong L, Tian J, He S, Zhu C, Wang J, Liu C, et al. Possible Vertical Transmission of SARS-CoV-2 from an Infected Mother to Her Newborn. Vol. 323, JAMA - Journal of the American Medical Association. American Medical Association; 2020.p. 1846-8. [Crossref]
- Selim M, Mohamed S, Abdo M, Abdelhaffez A. Is COVID-19 Similar in Pregnant and Non-Pregnant Women? Cureus. 2020;12(6). [Crossref]
- Huntley BJF, Huntley ES, Di Mascio D, Chen T, Berghella V, Chauhan SP. Rates of maternal and perinatal mortality and vertical transmission in pregnancies complicated by severe acute respiratory syndrome coronavirus 2 (SARS-Co-V-2) infection: A systematic review. Vol. 136, Obstetrics and Gynecology. Lippincott Williams and Wilkins; 2020. p. 303-12. [Crossref]
- Dorélien A. The Effects of In Utero Exposure to Influenza on Birth and Infant Outcomes in the US. Popul Dev Rev. 2019;45(3): 489-523. [Crossref]
- Bellos I, Pandita A, Panza R. Maternal and perinatal outcomes in pregnant women infected by SARS-CoV-2: A meta-analysis. 2020. [Crossref]
- Joseph NT, Rasmussen SA, Jamieson DJ. The effects of COVID-19 on pregnancy and implications for reproductive medicine. Fertil Steril. 2020. [Crossref]
- Prabhu M, Cagino K, Matthews KC, Friedlander RL, Glynn SM, Kubiak JM, et al. Pregnancy and postpartum outcomes in a universally tested population for SARS-CoV-2 in New York City: a prospective cohort study. BJOG An Int J Obstet Gynaecol. 2020; 127(12):1548-56. [Crossref]
- Chawanpaiboon S, Vogel JP, Moller AB, Lumbiganon P, Petzold M, Hogan D, et al. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. Lancet Glob Heal. 2019;7(1):e37-46. [Crossref]
- Chen C, Zhang JW, Xia HW, Zhang HX, Betran AP, Zhang L, et al. Preterm birth in China between 2015 and 2016. Am J Public Health. 2019;109(11):1597-604. [Crossref]
- Martin JA, Hamilton BE, Osterman MJK, Driscoll AK. Births: Final Data for 2018 Figure 1. Number and rate of triplet and higher-order multiple births: United States, 1980-2018. Vol. 68. 2019.
- Khoury R, Bernstein PS, Debolt C, Stone J, Sutton DM, Simpson LL, et al. Characteristics and outcomes of 241 births to women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at Five New York City Medical Centers. Obstet Gynecol. 2020 Aug 1;136(2):273-82. [Crossref]
- Delahoy MJ, Whitaker M, O'Halloran A, Chai SJ, Kirley PD, Alden N, et al. Characteristics and Maternal and Birth Outcomes of Hospitalized Pregnant Women with Laboratory-Confirmed COVID-19 -COVID-NET, 13 States, March 1*August 22, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(38):1347-54. [Crossref]
- Ahlberg M, Neovius M, Saltvedt S, Söderling J, Pettersson K, Brandkvist C, et al. Association of SARS-CoV-2 Test Status and Pregnancy Outcomes. Vol. 324, JAMA - Journal of the American Medical Association. American Medical Association; 2020.p. 1782-5. [Crossref]
- Flaherman VJ, Afshar Y, Boscardin WJ, Keller RL, H Mardy A, Prahl MK, et al. Infant Outcomes Following Maternal Infection With Severe Acute Respiratory Syndrome Corona virus 2 (SARS-CoV-2): First Report From the Pregnancy Coronavirus Outcomes Registry (PRIORITY) Study. Clin Infect Dis. 2020. [Crossref]
- Qin S, Md W, Bilodeau-Bertrand M, Liu S, Auger N. The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis. 2021.
- Haye MT, Cartes G, Gutiérrez J, Ahumada P, Krause B, Merialdi M, et al. Maternal and perinatal outcomes in pregnant women with confirmed severe and mild COVID-19 at one large maternity hospital in Chile. J Matern Neonatal Med. 2021;1-6. [Crossref]
- Crispi F, Crovetto F, Larroya M, Camacho M, Tortajada M, Sibila O, et al. Low birth weight as a potential risk factor for severe COVID-19 in adults. Sci Rep. 2021;11(1). [Crossref]
- Wang CL, Liu YY, Wu CH, Wang CY, Wang CH, Long CY. Impact of COVID-19 on Pregnancy. Int J Med Sci. 2021;2021(3):763-7. [Crossref]
- Racicot K, Mor G. Risks associated with viral infections during pregnancy. Vol. 127, Journal of Clinical Investigation. American Society for Clinical Investigation; 2017. p. 1591-9. [Crossref]
- Giakoumelou S, Wheelhouse N, Cuschieri K, Entrican G, Howie SEM, Horne AW. The role of infection in miscarriage. Hum Reprod Update. 2016;22(1):116-33. [Crossref]
- Liu H, Wang LL, Zhao SJ, Kwak-Kim J, Mor G, Liao AH. Why are pregnant women susceptible to COVID-19? An immunological viewpoint. Vol. 139, Journal of Reproductive Immunology. Elsevier Ireland Ltd; 2020. [Crossref]
- McNeil SA, Dodds LA, Fell DB, Allen VM, Halperin BA, Steinhoff MC, et al. Effect of respiratory hospitalization during pregnancy on infant outcomes. Vol. 204, American Journal of Obstetrics and Gynecology. Mosby Inc.; 2011. [Crossref]
- Pierce M, Kurinczuk JJ, Spark P, Brocklehurst P, Knight M. Perinatal outcomes after maternal 2009/H1N1 infection: National cohort study. BMJ. 2011;342(7811). [Crossref]
- Barker DJP, Osmond C, Kajantie E, Eriksson JG. Growth and chronic disease: Findings in the Helsinki Birth Cohort. Ann Hum Biol. 2009;36(5):445-58. [Crossref]
- Knop MR, Geng TT, Gorny AW, Ding R, Li C, Ley SH, et al. Birth weight and risk of type 2 diabetes mellitus, cardiovascular disease, and hypertension in adults: A meta-analysis of 7 646 267 participants from 135 studies. Vol. 7, Journal of the American Heart Association. American Heart Association Inc.; 2018. [Crossref]
- al-Haddad BJS, Oler E, Armistead B, Elsayed NA, Weinberger DR, Bernier R, et al. The fetal origins of mental illness. Vol. 221, American Journal of Obstetrics and Gynecology. Mosby Inc.; 2019.p. 549-62. [Crossref]
- Canetta SE, Bao Y, Co MDT, Ennis FA, Cruz J, Terajima M, et al. Serological documentation of maternal influenza exposure and bipolar disorder in adult offspring. Am J Psychiatry. 2014;171(5):557-63. [Crossref]
- Machón RA, Mednick SA, Huttunen MO. Adult major affective disorder after prenatal exposure to an influenza epidemic. Arch Gen Psychiatry. 1997;54(4):322-8. [Crossref]
- Mednick SA, Machon RA, Huttunen MO, Bonett D. Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic. Arch Gen Psychiatry. 1988;45(2):189-92. [Crossref]
- Al-Haddad BJS, Jacobsson B, Chabra S, Modzelewska D, Olson EM, Bernier R, et al. Long-term risk of neuropsychiatric disease after exposure to infection in utero. JAMA Psychiatry. 2019;76(6):594-602. [Crossref]
- Atladóttir HÓ, Thorsen P, Østergaard L, Schendel DE, Lemcke S, Abdallah M, et al. Maternal infection requiring hospitalization during pregnancy and autism spectrum disorders. J Autism Dev Disord. 2010;40(12):1423-30. [Crossref]