ISSN: 2148-8274 / E-ISSN: 2587-0084
, Türk Üreme Tıbbı ve Cerrahisi
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Turkish Journal of Reproductive Medicine and Surgery

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Erkek İnfertilitesinde Sperm Parametreleri ile Serum ve Seminal Plazma Çinko Düzeyleri İlişkisi
Relation of Sperm Parameters to Serum and Seminal Plasma Zinc Levels in Male Infertility
Received Date : 15 Aug 2024
Accepted Date : 06 Nov 2024
Available Online : 20 Nov 2024
Doi: 10.24074/tjrms.2024-105139 - Makale Dili: TR
Türk Üreme Tıbbı ve Cerrahisi Dergisi. 2024;8(3):83-90.
ÖZET
Amaç: Çinko gibi eser elementlerin eksikliği sık karşılaşılan erkek infertilitesi nedenleri arasında gösterilir. Bu çalışmada amaç, serum ve seminal sıvı çinko konsantrasyonları ile erkek infertilitesi ve sperm parametreleri arasındaki ilişkiyi değerlendirmektir. Gereç ve Yöntemler: Çalışma, erkek infertilitesi tanısı almış 100 katılımcı ile gerçekleştirildi. Katılımcılar semen parametrelerine göre dört gruba (normozoospermi, hafif oligozoospermi, şiddetli oligozoospermi, azoospermi); yaş gruplarına göre üç gruba ayrıldı. Semen parametreleri ve seminal plazma çinko seviyeleri, kan serumunda FSH, LH, LTH, serbest testosteron, toplam testosteron ve çinko düzeyleri karşılaştırıldı. Serum ve seminal plazmadaki çinko düzeyleri, normal ve anormal semen parametreleri ile motilite ve yaş grupları arasında karşılaştırıldı. Serum ve seminal plazma içerisindeki çinko miktarı atomik absorbsiyon spektrofotometresi ile ölçüldü. Bulgular: Katılımcıların semen volümü 2,75±1,29 ml, sperm konsantrasyonu 21,15±24,75 x106/ml, toplam motil sperm yüzdesi 43,69±29,13, seminal plazma ve serum çinko düzeyleri sırasıyla 3952,91±1694,77 μg/dl ve 121,75±119,94 μg/dl ölçüldü. Gruplar arası karşılaştırmada normozoospermiklere göre azoospermi grubunun yaş ortalaması, FSH ve LH düzeyleri ile semendeki lökosit sayısı yüksek (p=0,30; p=0,000; p=0,000; p=0,000), serbest testosteron ve toplam testosteron düzeyleri ise düşük bulundu (p=0,039; p=0,003). Ortalama serum prolaktin seviyesi, semen volümü, seminal plazma ve serum çinko değerleri açısından bir fark saptanmadı (p=0,136; p=0,65; p=0,65; p=0,38). Semen analizi normal ve anormal olan gruplarda, progresif motilite ≥%30 ve progresif motilite <%30 gruplarda ve yaş gruplarında seminal plazma ve serum çinko düzeyleri arasında anlamlı bir fark bulunmadı. Sonuç: Çalışmamızda azoospermik erkeklerde FSH, LH seviyeleri yüksek, serbest testosteron, total testosteron seviyeleri düşük bulunurken, seminal plazma ve serum Zn değerlerinde fark bulunmadı. Bu durum çalışmaya dahil edilen erkeklerin infertilite tanısı almış olmasıyla açıklanabilir.
ABSTRACT
Objective: Deficiency of trace elements such as zinc is one of the common causes of male infertility. The aim of this study was to evaluate the relationship between serum and seminal fluid zinc concentrations and male infertility and sperm parameters. Material and Methods: The study was conducted with 100 participants diagnosed with male infertility or unexplained infertility Participants were divided into four groups according to semen parameters (normozoospermia, mild oligozoospermia, severe oligozoospermia, azoospermia) and three groups according to age groups.The study was conducted with 100 participants diagnosed with male infertility. Participants were divided into four groups according to semen parameters (normozoospermia, mild oligozoospermia, severe oligozoospermia, azoospermia) and three groups according to age groups. Semen parameters and seminal plasma zinc levels, blood serum FSH, LH, LTH, free testosterone, total testosterone and zinc levels were compared. Zinc levels in serum and seminal plasma were compared between normal and abnormal semen parameters, motility and age groups. Zinc levels in serum and seminal plasma were measured by atomic absorption spectrophotometry. Results: Semen volume was 2.75±1.29 ml, sperm concentration 21.15±24.75 x106/ml, total motile sperm percentage 43.69±29.13, seminal plasma and serum zinc levels 3952.91±1694.77 μg/dl and 121.75±119.94 μg/dl, respectively. The mean age, FSH and LH levels and leukocyte count in semen were higher (p=0.30; p=0.000; p=0.000; p=0.000; p=0.000) and free testosterone and total testosterone levels were lower (p=0.039; p=0.003) in azoospermia group compared to normozoospermia group. There was no difference in mean serum prolactin level, semen volume, seminal plasma and serum zinc levels (p=0.136; p=0.65; p=0.65; p=0.38). No significant difference was found between seminal plasma and serum zinc levels in semen analysis normal and abnormal groups, progressive motility ≥30% and progressive motility <30% groups and age groups. Conclusion: In our study, FSH, LH levels were found to be high, free testosterone and total testosterone levels were found to be low, while no difference was found in seminal plasma and serum Zn levels in azoospermic men. This may be explained by the fact that the men included in the study were diagnosed with infertility.
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