ORİJİNAL ARAŞTIRMALAR
Endometriozisli Kadınlarda Obstetrik Sonuçların Değerlendirilmesi
Evaluation of Obstetric Outcomes in Women with Endometriosis
Received Date : 12 Sep 2024
Accepted Date : 05 Dec 2024
Available Online : 11 Dec 2024
Ufuk ATLIHANa, Ferruh ACETb, Onur YAVUZc, Burak ERSAKd, Can ATAe,
Tevfik Berk BİLDACIf, Selçuk ERKILINÇf, Hüseyin Aytuğ AVŞARg
aPrivate Karataş Hospital Gynecology and Obstetrics Clinic, İzmir, Türkiye
bEge University Faculty of Medicine, Health Application and Research Center, Department of Gynecology and Obstetrics, İzmir, Türkiye
cDokuz Eylül University Faculty of Medicine, Department of Gynecology and Obstetrics, İzmir, Türkiye
dAnkara Etlik City Hospital Gynecology and Obstetrics Clinic, Ankara, Türkiye
eBuca Seyfi Demirsoy Training and Research Hospital Gynecology and Obstetrics Clinic, İzmir, Türkiye
fIzmir Democracy University Faculty of Medicine, Buca Seyfi Demirsoy Training and Research Hospital, Department of Gynecology and Obstetrics, İzmir, Türkiye
gİzmir Tınaztepe University Private Galen Hospital, Department of Gynecology and Obstetrics, İzmir, Türkiye
Doi: 10.24074/tjrms.2024-105527 - Makale Dili: EN
Turkish Journal of Reproductive Medicine and Surgery. 2025;9(1):1-9.
ÖZET
Amaç: Endometriozisli kadınların endometriumunun anormal olduğu genel olarak kabul edilmektedir, ancak bu anormalliklerin gebelik sırasında
desidualizasyon ve plasentasyona zarar verip vermediği konusunda tartışmalar devam etmektedir. Bu çalışmanın amacı endometriozis tanısı
almış hastalarda obstetrik ve neonatal sonuçları değerlendirmektir. Gereç ve Yöntemler: 2018-2023 yılları arasında kadın doğum kliniğimizde
gebelik takibi yapılan ve hastanemizde doğum yapan 1015 hasta retrospektif olarak incelendi. Çalışmada değerlendirilen hastalar endometriozis
varlığına göre iki ayrı grupta değerlendirildi. Tüm hastalarda preterm doğum, gestasyonel diyabet (GDM), gestasyonel hipertansiyon (GHT),
preeklampsi, erken membran rüptürü (PROM), fetal büyüme kısıtlaması (FGR), Yenidoğan Yoğun Bakım Ünitesi (NICU) varlığı değerlendirildi.
Bulgular: ART öyküsü endometriozis grubunda anlamlı olarak daha yüksek saptandı (p=0.038). Gebelik haftasının endometriozis grubunda anlamlı
olarak daha düşük olduğu görüldü (p=0.018). GHT oranı endometriozis grubunda anlamlı olarak daha yüksek saptandı (p=0.034). Sezaryen
oranı endometriozis grubunda anlamlı olarak daha yüksek saptandı (p=0.037). Tahmini kan kaybı hacmi endometriozis grubunda anlamlı
olarak daha yüksek saptandı (p=0.042). NICU oranı endometriozis grubunda anlamlı olarak daha yüksek saptandı (p=0.044). Sonuç: Endometriozis
kaynaklı perinatal ve neonatal sonuçlar multifaktöriyel faktörlere bağlıdır. Olası riskleri açıklığa kavuşturmak için prospektif ve geniş popülasyon
tabanlı çalışmalara veya meta-analizlere ihtiyaç vardır.
Anahtar Kelimeler: Endometriozis; neonatal; perinatal
ABSTRACT
Objective: It is generally accepted that the endometrium of women with endometriosis is abnormal, although there is ongoing debate as to
whether these abnormalities impair decidualization and placentation during pregnancy. The aim of this study is to evaluate the obstetric and
neonatal outcomes in patients diagnosed with endometriosis. Material and Methods: 1015 patients who underwent pregnancy follow-up in our
obstetrics clinic and gave birth in our hospital between 2018 and 2023 were retrospectively examined. The patients evaluated in the study were
evaluated in two separate groups according to the presence of endometriosis. The presence of preterm delivery, gestational diabetes (GDM), gestational
hypertension (GHT), preeclampsia, premature rupture of membranes (PROM), fetal growth restriction (FGR), Neonatal Intensive Care
Unit (NICU) were evaluated in all patients. Results: ART presence was found to be significantly higher in the endometriosis group (p=0.038).
Gestational week was found to be significantly lower in the endometriosis group (p=0.018).The GHT presence was found to be significantly
higher in the endometriosis group (p=0.034). The Cesarean presence was found to be significantly higher in the endometriosis group (p=0.037).
Estimated blood loss volume was significantly higher in the endometriosis group (p=0.042). The NICU rate was significantly higher in the endometriosis
group (p=0.044). Conclusion: Perinatal and neonatal outcomes resulting from endometriosis depend on multifactorial factors.
Prospective and large population-based studies or meta-analyses are needed to clarify possible risks.
Keywords: Endometriosis; neonatal; perinatal
REFERANSLAR
- Atlıhan U, Ertan B, Özgözen E, Güney M. Comparison of Patients with Adenomyosis Detected in Hysterectomy Material and Patients with Other Benign Pathologies: Retrospective Study. Turkish Journal of Reproductive Medicine and Surgery. 2024;8(2):54-62. [Crossref]
- Kennedy S, Bergqvist A, Chapron C, D'Hooghe T, Dunselman G, Greb R, Hummelshoj L, Prentice A, Saridogan E. ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod. 2005;20:2698-704. [Crossref] [PubMed]
- Atlıhan U, Yavuz O, Avşar HA, Ata C, Erkılınç S, Bildacı TB. Vitamin D evaluation in adenomyosis: A retrospective cross-sectional study. Turk J Obstet Gynecol. 2024;21(2):98-103. [Crossref] [PubMed] [PMC]
- Buck Louis GM, Hediger ML, Peterson CM, Croughan M, Sundaram R, Stanford J, et al. ENDO Study Working Group. Incidence of endometriosis by study population and diagnostic method: the ENDO study. Fertil Steril. 2011;96(2):360-5. [Crossref] [PubMed] [PMC]
- Bean E, Naftalin J, Horne A, Saridogan E, Cutner A, Jurkovic D. Prevalence of deep and ovarian endometriosis in early pregnancy: ultrasound diagnostic study. Ultrasound Obstet Gynecol. 2022;59(1):107-113. [Crossref] [PubMed]
- Naftalin J, Hoo W, Pateman K, Mavrelos D, Holland T, Jurkovic D. How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic. Hum Reprod. 2012;27(12):3432-9. [Crossref] [PubMed]
- May KE, Villar J, Kirtley S, Kennedy SH, Becker CM. Endometrial alterations in endometriosis: a systematic review of putative biomarkers. Hum Reprod Update. 2011;17(5):637-53. [Crossref] [PubMed]
- Brosens I, Pijnenborg R, Benagiano G. Defective myometrial spiral artery remodelling as a cause of major obstetrical syndromes in endometriosis and adenomyosis. Placenta. 2013;34(2):100-5. [Crossref] [PubMed]
- Brosens I, Brosens JJ, Fusi L, Al-Sabbagh M, Kuroda K, Benagiano G. Risks of adverse pregnancy outcome in endometriosis. Fertil Steril. 2012;98(1):30-5. [Crossref] [PubMed]
- Fernando S, Breheny S, Jaques AM, Halliday JL, Baker G, Healy D. Preterm birth, ovarian endometriomata, and assisted reproduction technologies. Fertil Steril. 2009;91(2):325-30. [Crossref] [PubMed]
- Juang CM, Chou P, Yen MS, Twu NF, Horng HC, Hsu WL. Adenomyosis and risk of preterm delivery. BJOG. 2007;114(2):165-9. [Crossref] [PubMed]
- Stephansson O, Kieler H, Granath F, Falconer H. Endometriosis, assisted reproduction technology, and risk of adverse pregnancy outcome. Hum Reprod. 2009;24(9):2341-7. [Crossref] [PubMed]
- Omland AK, Abyholm T, Fedorcsák P, Ertzeid G, Oldereid NB, Bjercke S, et al. Pregnancy outcome after IVF and ICSI in unexplained, endometriosis-associated and tubal factor infertility. Hum Reprod. 2005;20(3):722-7. [Crossref] [PubMed]
- Vercellini P, Parazzini F, Pietropaolo G, et al. Pregnancy outcome in women with peritoneal, ovarian and rectovaginal endometriosis: a retrospective cohort study. BJOG 2012;119:1538-43. [Crossref] [PubMed]
- Benaglia L, Bermejo A, Somigliana E, Scarduelli C, Ragni G, Fedele L, Garcia-Velasco JA. Pregnancy outcome in women with endometriomas achieving pregnancy through IVF. Hum Reprod. 2012;27(6):1663-7. [Crossref] [PubMed]
- Mekaru K, Masamoto H, Sugiyama H, Asato K, Heshiki C, Kinjyo T, Aoki Y. Endometriosis and pregnancy outcome: are pregnancies complicated by endometriosis a high-risk group? Eur J Obstet Gynecol Reprod Biol. 2014;172: 36-9. [Crossref] [PubMed]
- Shmueli A, Salman L, Hiersch L, Ashwal E, Hadar E, Wiznitzer A, et al. Obstetrical and neonatal outcomes of pregnancies complicated by endometriosis. J Matern Fetal Neonatal Med. 2019;32(5):845-50. [Crossref] [PubMed]
- Saraswat L, Ayansina DT, Cooper KG, Bhattacharya S, Miligkos D, Horne AW, Bhattacharya S. Pregnancy outcomes in women with endometriosis: a national record linkage study. BJOG. 2017;124(3):444-52. [Crossref] [PubMed]
- Lin H, Leng JH, Liu JT, Lang JH. Obstetric outcomes in Chinese women with endometriosis: a retrospective cohort study. Chin Med J (Engl). 2015;128(4): 455-8. [Crossref] [PubMed] [PMC]
- Kuivasaari-Pirinen P, Raatikainen K, Hippeläinen M, Heinonen S. Adverse Outcomes of IVF/ICSI Pregnancies Vary Depending on Aetiology of Infertility. ISRN Obstet Gynecol. 2012;2012:451915. [Crossref] [PubMed] [PMC]
- Harmsen MJ, Van den Bosch T, de Leeuw RA, Dueholm M, Exacoustos C, Valentin L, et al. Consensus on revised definitions of Morphological Uterus Sonographic Assessment (MUSA) features of adenomyosis: results of modified Delphi procedure. Ultrasound Obstet Gynecol. 2022;60(1):118-31. [Crossref] [PubMed] [PMC]
- Atlıhan U. Myoma uteriye yaklaşım. Aslan M, Sarıtaş AG, Aksoy S, Atlıhan U, editörler. Sağlıkta Güncel Gelişmeler Işığında Teorik ve Klinik Yaklaşımlar-4. Bursa: Ekin Yayınevi; 2023. p.50-71.
- Pfeifer SM, Attaran M, Goldstein J, Lindheim SR, Petrozza JC, Rackow BW, et al. ASRM müllerian anomalies classification 2021. Fertil Steril. 2021;116(5): 1238-52. [Crossref] [PubMed]
- Guerriero S, Condous G, van den Bosch T, Valentin L, Leone FP, Van Schoubroeck D, et al. Systematic approach to sonographic evaluation of the pelvis in women with suspected endometriosis, including terms, definitions and measurements: a consensus opinion from the International Deep Endometriosis Analysis (IDEA) group. Ultrasound Obstet Gynecol. 2016;48(3): 318-32. [Crossref] [PubMed]
- American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2020. Diabetes Care. 2020;43(Suppl 1):S14-S31. [Crossref] [PubMed]
- ACOG Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia. Obstet Gynecol. 2019;133(1):1. [Crossref] [PubMed]
- Gordijn SJ, Beune IM, Thilaganathan B, Papageorghiou A, Baschat AA, Baker PN, et al. Consensus definition of fetal growth restriction: a Delphi procedure. Ultrasound Obstet Gynecol. 2016;48(3):333-9. [Crossref] [PubMed]
- Stafford I, Dildy GA, Clark SL, Belfort MA. Visually estimated and calculated blood loss in vaginal and cesarean delivery. Am J Obstet Gynecol. 2008;199(5):519.e1-7. [Crossref] [PubMed]
- Brosens I, Pijnenborg R, Vercruysse L, Romero R. The "Great Obstetrical Syndromes" are associated with disorders of deep placentation. Am J Obstet Gynecol. 2011;204(3):193-201. [Crossref] [PubMed] [PMC]
- Pizzo A, Salmeri FM, Ardita FV, Sofo V, Tripepi M, Marsico S. Behaviour of cytokine levels in serum and peritoneal fluid of women with endometriosis. Gynecol Obstet Invest. 2002;54(2):82-7. [Crossref] [PubMed]
- Rakhila H, Carli C, Daris M, Lemyre M, Leboeuf M, Akoum A. Identification of multiple and distinct defects in prostaglandin biosynthetic pathways in eutopic and ectopic endometrium of women with endometriosis. Fertil Steril. 2013;100(6):1650-9.e1-2. [Crossref] [PubMed]
- Harada T, Taniguchi F, Onishi K, Kurozawa Y, Hayashi K, Harada T; Japan Environment & Children's Study Group. Obstetrical Complications in Women with Endometriosis: A Cohort Study in Japan. PLoS One. 2016;11(12): e0168476. [Crossref] [PubMed] [PMC]
- Farland LV, Davidson S, Sasamoto N, Horne AW, Missmer SA. Adverse Pregnancy Outcomes in Endometriosis - Myths and Realities. Curr Obstet Gynecol Rep. 2020;9(1):27-35. [Crossref] [PubMed] [PMC]
- Petraglia F, Arcuri F, de Ziegler D, Chapron C. Inflammation: a link between endometriosis and preterm birth. Fertil Steril. 2012;98(1):36-40. [Crossref] [PubMed]
- Kunz G, Beil D, Huppert P, Leyendecker G. Structural abnormalities of the uterine wall in women with endometriosis and infertility visualized by vaginal sonography and magnetic resonance imaging. Hum Reprod. 2000;15(1):76-82. [Crossref] [PubMed]
- Aguilar HN, Mitchell BF. Physiological pathways and molecular mechanisms regulating uterine contractility. Hum Reprod Update. 2010;16(6):725-44. [Crossref] [PubMed]
- Lalani S, Choudhry AJ, Firth B, Bacal V, Walker M, Wen SW, et al. Endometriosis and adverse maternal, fetal and neonatal outcomes, a systematic review and meta-analysis. Hum Reprod. 2018;33(10):1854-65. [Crossref] [PubMed] [PMC]
- Breintoft K, Pinnerup R, Henriksen TB, Rytter D, Uldbjerg N, Forman A, Arendt LH. Endometriosis and Risk of Adverse Pregnancy Outcome: A Systematic Review and Meta-Analysis. J Clin Med. 2021;10(4):667. [Crossref] [PubMed] [PMC]
- Exacoustos C, Lauriola I, Lazzeri L, De Felice G, Zupi E. Complications during pregnancy and delivery in women with untreated rectovaginal deep infiltrating endometriosis. Fertil Steril. 2016;106(5):1129-35.e1. [Crossref] [PubMed]
- Farella M, Chanavaz-Lacheray I, Verspick E, Merlot B, Klapczynski C, Hennetier C, et al. Pregnancy outcomes in women with history of surgery for endometriosis. Fertil Steril. 2020;113(5):996-1004. [Crossref] [PubMed]
- Aris A. A 12-year cohort study on adverse pregnancy outcomes in Eastern Townships of Canada: impact of endometriosis. Gynecol Endocrinol. 2014;30(1):34-7. [Crossref] [PubMed]
- Mitri F, Casper RF. Endometriosis and mild bleeding disorders. Fertil Steril. 2015;103(4):886-7.e1. [Crossref] [PubMed]
- Katorza E, Soriano D, Stockheim D, Mashiach R, Zolti M, Seidman DS, et al. Severe intraabdominal bleeding caused by endometriotic lesions during the third trimester of pregnancy. Am J Obstet Gynecol. 2007;197(5):501.e1-4. [Crossref] [PubMed]
- Barbieri M, Somigliana E, Oneda S, Ossola MW, Acaia B, Fedele L. Decidualized ovarian endometriosis in pregnancy: a challenging diagnostic entity. Hum Reprod. 2009;24(8):1818-24. [Crossref] [PubMed]
- Canlorbe G, Goubin-Versini I, Azria E, Abdul-Razak R, Muray J-M. La deciduose ectopique: variabilites de presentation pendant la grossesse et di agnostics differentiels. Gynecol Obstet Fertil. 2012;40:235-40. [Crossref] [PubMed]
- Bean E, Cutner A, Saridogan E, Wong M, Naftalin J, Jurkovic D. Hemoperitoneum as a precursor of deep pelvic endometriosis: prospective cohort study. Ultrasound Obstet Gynecol. 2019;54(3):389-94. [Crossref] [PubMed]
- Lafleur N, Wei SQ, Bilodeau-Bertrand M, Auger N. Association of Endometriosis and Severe Maternal Morbidity. Obstet Gynecol. 2022;140(6): 1008-16. [Crossref] [PubMed]
- Glavind MT, Forman A, Arendt LH, Nielsen K, Henriksen TB. Endometriosis and pregnancy complications: a Danish cohort study. Fertil Steril. 2017;107 (1):160-6. [Crossref] [PubMed]
- Chen I, Lalani S, Xie RH, Shen M, Singh SS, Wen SW. Association between surgically diagnosed endometriosis and adverse pregnancy outcomes. Fertil Steril. 2018;109(1):142-7. [Crossref] [PubMed]
- Farland LV, Prescott J, Sasamoto N, Tobias DK, Gaskins AJ, Stuart JJ, et al. Endometriosis and Risk of Adverse Pregnancy Outcomes. Obstet Gynecol. 2019;134(3):527-36. [Crossref] [PubMed] [PMC]
- Hadfield RM, Lain SJ, Raynes-Greenow CH, Morris JM, Roberts CL. Is there an association between endometriosis and the risk of pre-eclampsia? A population based study. Hum Reprod. 2009;24(9):2348-52. [Crossref] [PubMed]
- Vadillo-Ortega F, Estrada-Gutiérrez G. Role of matrix metalloproteinases in preterm labour. BJOG. 2005;112 Suppl 1:19-22. [Crossref] [PubMed]
- Pitsos M, Kanakas N. The role of matrix metalloproteinases in the pathogenesis of endometriosis. Reprod Sci. 2009;16(8):717-26. [Crossref] [PubMed]
- Conti N, Cevenini G, Vannuccini S, Orlandini C, Valensise H, Gervasi MT, et al. Women with endometriosis at first pregnancy have an increased risk of adverse obstetric outcome. J Matern Fetal Neonatal Med. 2015;28(15):1795-8. [Crossref] [PubMed]
- Pérez-López FR, Martínez-Domínguez SJ, Viñas A, Pérez-Tambo R, Lafita A, Lajusticia H, et al. Health Outcomes and Systematic Analyses (HOUSSAY) Project. Endometriosis and gestational diabetes mellitus risk: a systematic review and meta-analysis. Gynecol Endocrinol. 2018;34(5):363-9. [Crossref] [PubMed]
- Salmeri N, Li Piani L, Cavoretto PI, Somigliana E, Viganò P, Candiani M. Endometriosis increases the risk of gestational diabetes: a meta-analysis stratified by mode of conception, disease localization and severity. Sci Rep. 2023;13(1):8099. [Crossref] [PubMed] [PMC]
- Horton J, Sterrenburg M, Lane S, Maheshwari A, Li TC, Cheong Y. Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis. Hum Reprod Update. 2019;25(5):592-632. [Crossref] [PubMed]
- Becker CM, Bokor A, Heikinheimo O, Horne A, Jansen F, Kiesel L, et al. ESHRE Endometriosis Guideline Group. ESHRE guideline: endometriosis. Hum Reprod Open. 2022;2022(2):hoac009.
- Hager M, Wenzl R, Riesenhuber S, Marschalek J, Kuessel L, Mayrhofer D, et al. The Prevalence of Incidental Endometriosis in Women Undergoing Laparoscopic Ovarian Drilling for Clomiphene-Resistant Polycystic Ovary Syndrome: A Retrospective Cohort Study and Meta-Analysis. J Clin Med. 2019;8(8):1210. [Crossref] [PubMed] [PMC]